Coy O2 Controlled InVivo Cabinet System - Hypoxia Chamber

Description

O₂ Control Cabinet for InVivo Studies (Microaerophilic / Hypoxic)

For Animal Studies

The Coy InVivo Hypoxic Cabinet System is the only system of its type that is a hermetically sealed chamber and allows continuous control of oxygen. This hypoxic chamber allows animals to live at reduced or elevated O2 levels. The system features the ability to change the O2 levels between multiple set points in increments of 0.1%. Users need only to supply a gas source for nitrogen and oxygen. The System features an advance controller and sensor to precisely control your needs. Cabinet comes complete with fittings and pressure relief valve to make operation and set up easy.

Due to the wide variety of protocols on InVivo hypoxia studies Coy offers a complete line of options to ensure your animal care needs are met.

Coy O₂ Control InVivo Cabinets Options:

• Animal filtration system (option) — Long-term studies or high numbers of animals will require this filtration system to remove gaseous waste.
• Dynamic O₂ cycling (upgrade) — For studies requiring cycling O₂ levels for intermittent hypoxia, Coy offers a factory-installed option to ramp and cycle oxygen levels based on preset protocols in the O₂ control system.
• Added capacity for animal filtration — Additional filters to enhance the filtration system and adjust for the number of animals while easing maintenance time for lab personnel.
• Heaters — Internal heaters may be added if they are needed, available for Models 30 and 60.
• Compact dehumidifier — Easy-to-maintain unit provides a way to remove moisture without using a desiccant.
• Recirculating atmosphere filtration system — System filters the box atmosphere and controls contamination through a standard HEPA filter.

Humidity Consideration for InVivo Studies

Humidity from respiration should be controlled at least to non-condensing levels to provide an atmosphere that protects equipment and the sensors from condensation and is comfortable for the animals and users. The number of animals and the duration of hypoxic incubation will determine the appropriate humidity control solution for your study. Contact an expert at Coy Lab to discuss your options.

Periods of tissue hypoxia also develop in organs affected by atherosclerotic narrowing of nutritive arteries, during physical exercise and during acclimation to high altitude (Roels et al. 2007; Mounier et al. 2009).

Intermittent hypoxia has also been observed in rapidly growing tumors (Bhaskara et al. 2012), patients suffering from sickle cell anemia (Alexy et al. 2010) as well as in organs of premature infants (Poets et al. 1994; Stokowski 2005).